The Download: “reprogramming” aging, and the hidden sense of interoception

The idea is to treat the disease by regenerating healthy nerves in the eye—but the company already hopes to go further. If the treatment can reverse glaucoma, similar treatments could reverse other diseases of aging. Maybe, just maybe, they could reverse aging altogether.

The approach relies on “reprogramming” cells to a younger state. It’s one of many strategies being explored by biotech companies looking to slow and reverse aging. But of all of them, it seems to be the one that is truly taking off.

Read the full story on the pursuit of reprogramming for rejuvenation.

—Jessica Hamzelou

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Inside Interoception: The hidden sense of how you feel inside

Scientists have a word for how we sense ourselves from the inside: interoception. Today, thanks to a 2021 Nobel Prize and new tools that can map internal signaling across the body, research into interoception is taking off.

As researchers decode how signals move between body and brain, a clearer picture is starting to take shape—with implications for how we understand and treat conditions from obesity to chronic pain to anxiety.

Find out how it’s leading to a “new continent of awareness.”